Improved detection scheme for chipless RFIDs using prolate spheroidal wave function-based noise filtering

A novel, highly sensitive scheme to detect the resonance peaks in the spectrum of chipless RFID signals is presented. The detection is based on finding the zeros in the derivative of the group delay of the received signal. In order to be able to accurately detect these zeros in the presence of noise, the received signal is filtered using a prolate spheroidal wave function-based model. This allows great increases in the distance at which chipless RFIDs can be accurately read. The detection method can be used standalone or in addition to traditional amplitude-based detection schemes

Methodik für den Entwurf von kapazitätsoptimierten Mehrantennensystemen am Fahrzeug

In der vorliegenden Arbeit wird eine Methodik entwickelt und evaluiert, die es erlaubt Mehrantennensysteme zu optimieren. Schwerpunkt ist hierbei die Synthese kapazitätsoptimierter Richtcharakteristiken basierend auf spezifischen Einschränkungen des Antennendesigns. Die Grundidee hinter dieser Synthese ist es, Antennensysteme mit einem auf ein Volumen bezogenes Kanalwissen zu optimieren

Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulation.?

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Star Formation in Galaxy Mergers with Realistic Models of Stellar Feedback & the Interstellar Medium

We use simulations with realistic models for stellar feedback to study galaxy mergers. These high resolution (1 pc) simulations follow formation and destruction of individual GMCs and star clusters. The final starburst is dominated by in situ star formation, fueled by gas which flows inwards due to global torques. The resulting high gas density results in rapid star formation. The gas is self gravitating, and forms massive (~10^10 M_sun) GMCs and subsequent super-starclusters (masses up to 10^8 M_sun). However, in contrast to some recent simulations, the bulk of new stars which eventually form the central bulge are not born in superclusters which then sink to the center of the galaxy, because feedback efficiently disperses GMCs after they turn several percent of their mass into stars. Most of the mass that reaches the nucleus does so in the form of gas. The Kennicutt-Schmidt law emerges naturally as a consequence of feedback balancing gravitational collapse, independent of the small-scale star formation microphysics. The same mechanisms that drive this relation in isolated galaxies, in particular radiation pressure from IR photons, extend over seven decades in SFR to regulate star formation in the most extreme starbursts (densities >10^4 M_sun/pc^2). Feedback also drives super-winds with large mass loss rates; but a significant fraction of the wind material falls back onto the disks at later times, leading to higher post-starburst SFRs in the presence of stellar feedback. Strong AGN feedback is required to explain sharp cutoffs in star formation rate. We compare the predicted relic structure, mass profile, morphology, and efficiency of disk survival to simulations which do not explicitly resolve GMCs or feedback. Global galaxy properties are similar, but sub-galactic properties and star formation rates can differ significantly.Comment: 17 pages, 13 figures (+appendices), MNRAS accepted (matches published). Movies of the simulations are available at http://www.tapir.caltech.edu/~phopkins/Site/Movies_sbw_mgr.htm

The Nlrp3 inflammasome regulates acute graft-versus-host disease

The success of allogeneic hematopoietic cell transplantation is limited by acute graft-versus-host disease (GvHD), a severe complication accompanied by high mortality rates. Yet, the molecular mechanisms initiating this disease remain poorly defined. In this study, we show that, after conditioning therapy, intestinal commensal bacteria and the damage-associated molecular pattern uric acid contribute to Nlrp3 inflammasome-mediated IL-1β production and that gastrointestinal decontamination and uric acid depletion reduced GvHD severity. Early blockade of IL-1β or genetic deficiency of the IL-1 receptor in dendritic cells (DCs) and T cells improved survival. The Nlrp3 inflammasome components Nlrp3 and Asc, which are required for pro-IL-1β cleavage, were critical for the full manifestation of GvHD. In transplanted mice, IL-1β originated from multiple intestinal cell compartments and exerted its effects on DCs and T cells, the latter being preferentially skewed toward Th17. Compatible with these mouse data, increased levels of active caspase-1 and IL-1β were found in circulating leukocytes and intestinal GvHD lesions of patients. Thus, the identification of a crucial role for the Nlrp3 inflammasome sheds new light on the pathogenesis of GvHD and opens a potential new avenue for the targeted therapy of this severe complication

Suppression of Soft Tissue Sarcoma Growth by a Host Defense-Like Lytic Peptide

BACKGROUND: Soft tissue sarcoma (STS) is an anatomically and histologically heterogeneous neoplasia that shares a putative mesenchymal cell origin. The treatment with common chemotherapeutics is still unsatisfying because of association with poor response rates. Although evidence is accumulating for potent oncolytic activity of host defense peptides (HDPs), their potential therapeutic use is often limited by poor bioavailability and inactivation in serum. Therefore, we tested the designer host defense-like lytic D,L-amino acid peptide [D]-K3H3L9 on two STS cell lines in vitro and also in an athymic and syngeneic mouse model. In recent studies the peptide could show selectivity against prostate carcinoma cells and also an active state in serum. METHODS: In vitro the human synovial sarcoma cell line SW982, the murine fibrosarcoma cell line BFS-1 and primary human fibroblasts as a control were exposed to [D]-K3H3L9, a 15mer D,L-amino acid designer HDP. Cell vitality in physiological and acidic conditions (MTT-assay), cell growth (BrdU) and DNA-fragmentation (TUNEL) were investigated. Membrane damage at different time points could be analyzed with LDH assay. An antibody against the tested peptide and recordings using scanning electron microscopy could give an inside in the mode of action. In vivo [D]-K3H3L9 was administered intratumorally in an athymic and syngeneic (immunocompetent) mouse model with SW982 and BFS-1 cells, respectively. After three weeks tumor sections were histologically analyzed. RESULTS: The peptide exerts rapid and high significant cytotoxicity and antiproliferating activity against the malignant cell lines, apparently via a membrane disrupting mode of action. The local intratumoral administration of [D]-K3H3L9 in the athymic and syngeneic mice models significantly inhibited tumor progression. The histological analyses of the tumor sections revealed a significant antiproliferative, antiangiogenic activity of the treatment group. CONCLUSION: These findings demonstrate the in vitro and in vivo oncolytic activity of [D]-K3H3L9 in athymic and syngeneic mouse models

Methodik für den Entwurf von kapazitätsoptimierten Mehrantennensystemen am Fahrzeug

In der vorliegenden Arbeit wird eine Methodik entwickelt und evaluiert, die es erlaubt Mehrantennensysteme zu optimieren. Schwerpunkt ist hierbei die Synthese kapazitätsoptimierter Richtcharakteristiken basierend auf spezifischen Einschränkungen des Antennendesigns. Die Grundidee hinter dieser Synthese ist es, Antennensysteme mit einem auf ein Volumen bezogenes Kanalwissen zu optimieren